Ruxolitinib API And Intermediates
Ruxolitinib is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.
Ruxolitinib is a Janus kinase inhibitor that is used in the treatment of intermediate or high risk myelofibrosis and resistant forms of polycythemia vera and graft-vs-host disease. Ruxolitinib is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury and to cases of reactivation of hepatitis B in susceptible individuals.
Ruxolitinib cas 941678-49-5; INCB018424; Ruxolitinib (INCB018424); (R)-3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-3-Cyclopentylpropanenitrile; INCB-018424; INCB 018424; UNII-82S8X8XX8H;
Ruxolitinib cas 941678-49-5,Ruxolitinib cas 2075-45-8,Ruxolitinib cas 269410-08-4,Ruxolitinib cas 941685-26-3,Ruxolitinib cas 941685-27-4 Offering.
Ruxolitinib cas 941678-49-5,Ruxolitinib cas 2075-45-8,Ruxolitinib cas 269410-08-4,Ruxolitinib cas 941685-26-3,Ruxolitinib cas 941685-27-4 Â Shandong Haohong Biotechnology Co., Ltd. , https://www.haohongpharma.com
Gate valves are widely used in water systems such as water treatment plants, distribution networks, potable water applications; Sewage systems such as sewage treatment plants, raw water, digested sewage,air applications ; Industrial systems such as chemical contaminated waste water, gases, industrial media, sea water applications and Food & Beverage systems such as washing and rinsing applications, conveying systems, potable water processing.Â
Item
Swing check valve
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Standard
Design and manufacture standard
DIN3356
Face to face dimension
DIN3202 F1
Flange drilling
EN1092-2
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Specification
Norminal Pressure
1.6Mpa
Suitable Medium
Water
Test Pressure
Shell
2.4Mpa
Seat
1.76Mpa
Test Time
DN50-DN150
60S
DN150 and up
120S
Temperature
<100ºC
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Product Features
1
Full port
2
Solid and resilient disc
3
Bolted cover
5
Low torque operation
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Material list
Body
CI/DI GGG40/GGG50
Wedge
CI/DI GGG40/GGG50+EPDM
Stem
2cr13/SS304/SSS316
Seat
Metal seat / EPDM seat
Bolts and Nuts
Zinc plated carbon steel
Coating
A
Fusion Bonded Epoxy powder coated
B
Spray Painting
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Face to face dimension
Size
Length
DN40
200MM
DN50
230MM
DN65
290MM
DN80
310MM
DN100
350MM
DN125
400MM
DN150
480MM
DN200
600MM
DN250
730MM
DN300
850MM
Inspection:
Package: All check valves packed into plywood cases
Company profile:
Certificate:
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DIN3356 Swing Check Valve
Model NO.: DIN3356
Flow Direction: Unidirection
Standard: DIN
Application: Industrial Usage, Water Industrial Usage, Household Usage, Pipeline
Body: Ci Di Ss
Seat: EPDM;NBR
Actuator: Hand Level
Disc: Ci/Di+Nickle Plated;CF8;CF8m
Inspection: API598
Face to Face: En558-1 20 Series
Trademark: Eathu
Transport Package: Check Valve Are Packed Into Plywood Case
Specification: DN 15- DN 1200
Origin: Qingdao, China
HS Code: 8481804090
Swing Check valve fields of application